Description

The Role:

Generate Biomedicines is seeking a Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology, contributing to our mission of accelerating drug discovery through advanced imaging technologies.

How You Will Contribute:
-Drive the advancement of experiments and technologies by performing protein purification, complexation, vitrification, and clipping, ensuring high-quality sample preparation for CryoEM.
-Operate CryoEM microscopes and execute automated data collection workflows with minimal guidance.
-Interpret and troubleshoot experimental data, contributing to planning and prioritization of concurrent CryoEM experiments.
-Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
-Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
-Document experimental data and report findings in internal databases.
-Contribute to process optimization and implementation of new protocols.

Requirements

Qualifications:
-Recombinant protein expression in E. coli and mammalian cell lines, protein purification (ÄKTA-based), and associated analytical techniques (aSEC, DSF, SDS-PAGE).
-Demonstrated ability to work independently with minimal guidance while contributing to a collaborative research environment.
-Excellent troubleshooting and attention to detail.

Preferred Additional Skills:
-Prior exposure to CryoEM workflows or microscope operation (e.g., SerialEM, Vitrobot, GP2).
-Hands-on experience with liquid handlers (Tecan, Hamilton).
-Experience running binding assays (e.g., Octet or Gator Bio).

Experience
-Bachelors Degree with 4+ or Masters Degree with 2+ years of experience.